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Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Δ-9-tetrahydrocannabinol
1. Tolerance and dependence induced by chronic Δ-9-tetrahydrocannabinol (THC) administration were investigated in mice. The effects on body weight, analgesia and hypothermia were measured during 6 days of treatment (10 or 20 mg kg(−1) THC twice daily). A rapid tolerance to the acute effects was obse...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1565737/ https://ncbi.nlm.nih.gov/pubmed/9884086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702228 |
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