Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination

Metabolic insult results in apoptosis and depletion of mature oligodendrocytes during demyelination. To examine the role of insulin-like growth factor-1 (IGF-1) during acute demyelination and remyelination in the adult CNS, we exposed transgenic mice that continuously express IGF-1 (IGF-1 tg) to cup...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Mason, J. L., Ye, P., Suzuki, K., D'Ercole, A. J., Matsushima, G. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772563/
https://ncbi.nlm.nih.gov/pubmed/10908609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-15-05703.2000
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