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Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C

We have identified a mechanism, mediated by the ε isozyme of protein kinase C (PKCε) in peripheral neurons, which may have a role in chronic inflammatory pain. Acute inflammation, produced by carrageenan injection in the rat hindpaw, produced mechanical hyperalgesia that resolved by 72 hr. However,...

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Publicado en:J Neurosci
Autores principales: Aley, K. O., Messing, Robert O., Mochly-Rosen, Daria, Levine, Jon D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772473/
https://ncbi.nlm.nih.gov/pubmed/10844037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-12-04680.2000
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