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Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 In Vivo

Recently we have shown that the majority of retinal ganglion cells (RGCs) dies via activation of caspase-3 after transection of the optic nerve (ON) in the adult rat. In the present study we investigated whether insulin-like growth factor-I (IGF-I), an important factor in retinal development, preven...

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Библиографические подробности
Опубликовано в: :J Neurosci
Главные авторы: Kermer, Pawel, Klöcker, Nikolaj, Labes, Monika, Bähr, Mathias
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2000
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772394/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-02-00722.2000
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