The Cytosolic Antioxidant Copper/Zinc-Superoxide Dismutase Prevents the Early Release of Mitochondrial Cytochrome c in Ischemic Brain after Transient Focal Cerebral Ischemia in Mice

Release of mitochondrial cytochrome c into the cytosol is a critical step in apoptosis. We have reported that early release of cytochrome c in vivo occurs after permanent focal cerebral ischemia (FCI) and is mediated by the mitochondrial antioxidant manganese superoxide dismutase (SOD). However, the...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fujimura, Miki, Morita-Fujimura, Yuiko, Noshita, Nobuo, Sugawara, Taku, Kawase, Makoto, Chan, Pak H.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2000
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772210/
https://ncbi.nlm.nih.gov/pubmed/10751433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-08-02817.2000
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