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A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations

With advancement of technologies such as genomic sequencing, predictive biomarkers have become a useful tool for the development of personalized medicine. Predictive biomarkers can be used to select subsets of patients, which are most likely to benefit from a treatment. A number of approaches for su...

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Publicat a:Pharm Stat
Autors principals: Huber, Cynthia, Benda, Norbert, Friede, Tim
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772173/
https://ncbi.nlm.nih.gov/pubmed/31270933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pst.1951
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