RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis

The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are conserved in the human KANSL complex: Nsl1/Wah (KANSL1), Dgt1/Nsl2 (KANSL2), Rcd1/Nsl3 (KANSL3), Rcd5 (MCRS1), MBD-R2 (PHF20), Wds (WDR5) and Mof (...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Genet
Main Authors: Pavlova, Gera A., Popova, Julia V., Andreyeva, Evgeniya N., Yarinich, Lyubov A., Lebedev, Mikhail O., Razuvaeva, Alyona V., Dubatolova, Tatiana D., Oshchepkova, Anastasiya L., Pellacani, Claudia, Somma, Maria Patrizia, Pindyurin, Alexey V., Gatti, Maurizio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772098/
https://ncbi.nlm.nih.gov/pubmed/31527906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008371
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items