RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis

The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are conserved in the human KANSL complex: Nsl1/Wah (KANSL1), Dgt1/Nsl2 (KANSL2), Rcd1/Nsl3 (KANSL3), Rcd5 (MCRS1), MBD-R2 (PHF20), Wds (WDR5) and Mof (...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Pavlova, Gera A., Popova, Julia V., Andreyeva, Evgeniya N., Yarinich, Lyubov A., Lebedev, Mikhail O., Razuvaeva, Alyona V., Dubatolova, Tatiana D., Oshchepkova, Anastasiya L., Pellacani, Claudia, Somma, Maria Patrizia, Pindyurin, Alexey V., Gatti, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772098/
https://ncbi.nlm.nih.gov/pubmed/31527906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008371
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