RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis

The Drosophila Nonspecific Lethal (NSL) complex is a major transcriptional regulator of housekeeping genes. It contains at least seven subunits that are conserved in the human KANSL complex: Nsl1/Wah (KANSL1), Dgt1/Nsl2 (KANSL2), Rcd1/Nsl3 (KANSL3), Rcd5 (MCRS1), MBD-R2 (PHF20), Wds (WDR5) and Mof (...

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Udgivet i:PLoS Genet
Main Authors: Pavlova, Gera A., Popova, Julia V., Andreyeva, Evgeniya N., Yarinich, Lyubov A., Lebedev, Mikhail O., Razuvaeva, Alyona V., Dubatolova, Tatiana D., Oshchepkova, Anastasiya L., Pellacani, Claudia, Somma, Maria Patrizia, Pindyurin, Alexey V., Gatti, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772098/
https://ncbi.nlm.nih.gov/pubmed/31527906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008371
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