Abnormalities of mucosal serotonin metabolism and 5‐HT(3) receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron

BACKGROUND: Irritable bowel syndrome with diarrhoea (IBS‐D) is a common condition, greatly reducing the quality of life with few effective treatment options available. AIM: To report the beneficial response shown in our trial with the 5‐hydroyxtryptamine (5‐HT) receptor 3 antagonist, ondansetron in...

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Опубликовано в: :Aliment Pharmacol Ther
Главные авторы: Gunn, David, Garsed, Klara, Lam, Ching, Singh, Gulzar, Lingaya, Melanie, Wahl, Verena, Niesler, Beate, Henry, Amanda, Hall, Ian P., Whorwell, Peter, Spiller, Robin
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Predictors of Responsiveness to Ondansetron in Ibs‐d
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772086/
https://ncbi.nlm.nih.gov/pubmed/31342534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/apt.15420
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