The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas

Defective DNA damage response (DDR) is frequently associated with tumorigenesis. Abrogation of DDR leads to genomic instability, which is one of the most common characteristics of human cancers. TP53 mutations with gain-of-function activity are associated with tumors under high replicative stress, h...

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Bibliografiska uppgifter
I publikationen:Cancers (Basel)
Huvudupphovsmän: Valenti, Fabio, Sacconi, Andrea, Ganci, Federica, Grasso, Giuseppe, Strano, Sabrina, Blandino, Giovanni, Di Agostino, Silvia
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6771082/
https://ncbi.nlm.nih.gov/pubmed/31514456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091347
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