Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells

Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated in CRC tissues and associated with drug resistance. Sensitization to 5-FU, oxaliplatin, and irinotecan by transfection with miR-195-5p and mi...

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Veröffentlicht in:Cells
Hauptverfasser: Poel, Dennis, Boyd, Lenka N.C., Beekhof, Robin, Schelfhorst, Tim, Pham, Thang V., Piersma, Sander R., Knol, Jaco C., Jimenez, Connie R., Verheul, Henk M.W., Buffart, Tineke E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770888/
https://ncbi.nlm.nih.gov/pubmed/31546954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8091111
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