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Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

The endocannabinoid system represents an integrated neuronal network involved in the control of several organisms’ functions, such as feeding behavior. A series of hybrids of 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (mimonabant), a well-known i...

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Détails bibliographiques
Publié dans:Biomolecules
Auteurs principaux: Dimmito, Marilisa P., Stefanucci, Azzurra, Pieretti, Stefano, Minosi, Paola, Dvorácskó, Szabolcs, Tömböly, Csaba, Zengin, Gokhan, Mollica, Adriano
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770484/
https://ncbi.nlm.nih.gov/pubmed/31527522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9090492
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