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IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism
Insulin-degrading enzyme (IDE) was applied to catalyze hydrolysis of Nociceptin/Orphanin 1-16 (OFQ/N) to show the involvement of the enzyme in degradation of neuropeptides engaged in pain transmission. Moreover, IDE degradative action towards insulin (Ins) was inhibited by the OFQ/N fragments, sugge...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6770469/ https://ncbi.nlm.nih.gov/pubmed/31509943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184447 |
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