Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

We examined the anti-cancer effect of genistein, a soy-derived isoflavone, in human bladder transitional cell carcinoma T24 cells. According to our data, genistein induced G2/M phase arrest of the cell cycle and apoptosis. Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulat...

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Vydáno v:Antioxidants (Basel)
Hlavní autoři: Park, Cheol, Cha, Hee-Jae, Lee, Hyesook, Hwang-Bo, Hyun, Ji, Seon Yeong, Kim, Min Yeong, Hong, Su Hyun, Jeong, Jin-Woo, Han, Min Ho, Choi, Sung Hyun, Jin, Cheng-Yun, Kim, Gi-Young, Choi, Yung Hyun
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769882/
https://ncbi.nlm.nih.gov/pubmed/31438633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8090327
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