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Sulfated Glycoaminoglycans and Proteoglycan Syndecan-4 Are Involved in Membrane Fixation of LL-37 and Its Pro-Migratory Effect in Breast Cancer Cells

Initially characterized by its antimicrobial activities, LL-37 has also been shown to significantly contribute to tumor development. On breast cancer cell lines, LL-37 increases intracellular calcium via the TRPV2 channel and their migration via the activation of PI3K/AKT signaling. Its all-d enanti...

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Publicat a:Biomolecules
Autors principals: Habes, Chahrazed, Weber, Günther, Goupille, Caroline
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769752/
https://ncbi.nlm.nih.gov/pubmed/31547381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9090481
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