The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy

The heparan sulfate proteoglycan syndecan-1 is expressed by myeloma cells and shed into the myeloma microenvironment. High levels of shed syndecan-1 in myeloma patient sera correlate with poor prognosis and studies in animal models indicate that shed syndecan-1 is a potent stimulator of myeloma tumo...

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Autores principales: Yang, Yang, MacLeod, Veronica, Dai, Yuemeng, Khotskaya-Sample, Yekaterina, Shriver, Zachary, Venkataraman, Ganesh, Sasisekharan, Ram, Naggi, Annamaria, Torri, Giangiacomo, Casu, Benito, Vlodavsky, Israel, Suva, Larry J., Epstein, Joshua, Yaccoby, Shmuel, Shaughnessy, John D., Barlogie, Bart, Sanderson, Ralph D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976367/
https://ncbi.nlm.nih.gov/pubmed/17536013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-082495
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