Diet-Induced Obese Mice and Leptin-Deficient Lep(ob/ob) Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

As glucose-dependent insulinotropic polypeptide (GIP) possesses pro-adipogenic action, the suppression of the GIP hypersecretion seen in obesity might represent a novel therapeutic approach to the treatment of obesity. However, the mechanism of GIP hypersecretion remains largely unknown. In the pres...

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Udgivet i:Int J Mol Sci
Main Authors: Lee, Eunyoung, Miedzybrodzka, Emily L., Zhang, Xilin, Hatano, Ryo, Miyamoto, Junki, Kimura, Ikuo, Fujimoto, Kosuke, Uematsu, Satoshi, Rodriguez-Cuenca, Sergio, Vidal-Puig, Antonio, Gribble, Fiona M., Reimann, Frank, Miki, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769670/
https://ncbi.nlm.nih.gov/pubmed/31509948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184448
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