Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations

Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3′-UTR of mRNAs of eukaryotic selenoproteins. SECIS-binding protein 2 (SECISBP2) increases the efficiency of this process. Pathogenic mutations in SECISBP2 reduce sel...

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Udgivet i:J Biol Chem
Main Authors: Zhao, Wenchao, Bohleber, Simon, Schmidt, Henrik, Seeher, Sandra, Howard, Michael T., Braun, Doreen, Arndt, Simone, Reuter, Uschi, Wende, Hagen, Birchmeier, Carmen, Fradejas-Villar, Noelia, Schweizer, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768643/
https://ncbi.nlm.nih.gov/pubmed/31350336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009369
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