Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations

Recoding of UGA codons as selenocysteine (Sec) codons in selenoproteins depends on a selenocysteine insertion sequence (SECIS) in the 3′-UTR of mRNAs of eukaryotic selenoproteins. SECIS-binding protein 2 (SECISBP2) increases the efficiency of this process. Pathogenic mutations in SECISBP2 reduce sel...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Zhao, Wenchao, Bohleber, Simon, Schmidt, Henrik, Seeher, Sandra, Howard, Michael T., Braun, Doreen, Arndt, Simone, Reuter, Uschi, Wende, Hagen, Birchmeier, Carmen, Fradejas-Villar, Noelia, Schweizer, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Editors' Picks
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768643/
https://ncbi.nlm.nih.gov/pubmed/31350336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009369
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares