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Generation of Quiescent Cardiac Fibroblasts from Human Induced Pluripotent Stem Cells for In Vitro Modeling of Cardiac Fibrosis

RATIONALE: Activated fibroblasts are the major cell type that secrete excessive extracellular matrix in response to injury, contributing to pathological fibrosis and leading to organ failure. Effective anti-fibrotic therapeutic solutions, however, are not available due to the poorly defined characte...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Zhang, Hao, Tian, Lei, Shen, Mengcheng, Tu, Chengyi, Wu, Haodi, Gu, Mingxia, Paik, David T., Wu, Joseph C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768436/
https://ncbi.nlm.nih.gov/pubmed/31288631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315491
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