Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents

BACKGROUND: Nitrogen heterocyclic rings and sulfonamides have attracted attention of several researchers. RESULTS: A series of regioselective imidazole-based mono- and bis-1,4-disubstituted-1,2,3-triazole-sulfonamide conjugates 4a–f and 6a–f were designed and synthesized. The first step in the synth...

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Dettagli Bibliografici
Pubblicato in:Chem Cent J
Autori principali: Al-blewi, Fawzia Faleh, Almehmadi, Meshal A., Aouad, Mohamed Reda, Bardaweel, Sanaa K., Sahu, Pramod K., Messali, Mouslim, Rezki, Nadjet, El Ashry, El Sayed H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768023/
https://ncbi.nlm.nih.gov/pubmed/30387018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0479-1
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