Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes

The blistering disease recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in the gene encoding collagen VII (COL7), which forms anchoring fibrils that attach the epidermis to the dermis. Cutaneous gene therapy to restore COL7 expression in RDEB patient cells has been proposed,...

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Detalhes bibliográficos
Publicado no:Cell Transplant
Main Authors: Supp, Dorothy M., Hahn, Jennifer M., Combs, Kelly A., McFarland, Kevin L., Schwentker, Ann, Boissy, Raymond E., Boyce, Steven T., Powell, Heather M., Lucky, Anne W.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767893/
https://ncbi.nlm.nih.gov/pubmed/31271052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0963689719857657
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