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Pharmacokinetic Properties of Ibuprofen (IBU) From the Fixed‐Dose Combination IBU/Caffeine (400/100 mg; FDC) in Comparison With 400 mg IBU as Acid or Lysinate Under Fasted and Fed Conditions—Data From 2 Single‐Center, Single‐Dose, Randomized Crossover Studies in Healthy Volunteers
Rapid onset of analgesic action is linked with rapid absorption of analgesics (high maximum concentration [C(max)] and short time to maximum concentration [t(max)]). After overnight fasting, ibuprofen lysinate reaches higher peak plasma levels (C(max)) earlier than ibuprofen acid (t(max)) with compa...
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| Publicado no: | Clin Pharmacol Drug Dev |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767367/ https://ncbi.nlm.nih.gov/pubmed/30897305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.672 |
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