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Loss of primary cilia increases polycystin-2 and TRPV4 and the appearance of a nonselective cation channel in the mouse cortical collecting duct
Flow-related bending of cilia results in Ca(2+) influx through a polycystin-1 (Pkd1) and polycystin-2 (Pkd2) complex, both of which are members of the transient receptor potential (TRP) family (TRPP1 and TRPP2, respectively). Deletion of this complex as well as cilia result in polycystic kidney dise...
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| Publicado no: | Am J Physiol Renal Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6766628/ https://ncbi.nlm.nih.gov/pubmed/31313950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00210.2019 |
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