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How do mutations affecting the breast cancer genes BRCA1 and BRCA2 cause cancer susceptibility?
The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes with a high penetrance to several forms of epithelial malignancy. The large, nuclear-localized BRCA proteins act as custodians of chromosome integrity through distinct functions in the assembly and activity of mac...
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| Pubblicato in: | DNA Repair (Amst) |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765401/ https://ncbi.nlm.nih.gov/pubmed/31337537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102668 |
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