Downregulated MCOLN1 Attenuates The Progression Of Non-Small-Cell Lung Cancer By Inhibiting Lysosome-Autophagy

OBJECTIVES: Autophagy plays various roles in non-small-cell lung cancer (NSCLC). MCOLN1, a reactive oxygen species sensor, can regulate autophagy via lysosomal Ca(2+); however, the role of MCOLN1 in NSCLC is largely unknown. This study aimed to explore the effects of MCOLN1 on proliferation, invasio...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Yin, Chuntong, Zhang, Han, Liu, Xin, Zhang, Haiying, Zhang, Yue, Bai, Xue, Wang, Lei, Li, Huimin, Li, Xia, Zhang, Shuqian, Zhang, Linyou, Zhang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765329/
https://ncbi.nlm.nih.gov/pubmed/31576167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S216538
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