PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors

Histone H3 lysine 9 methylation (H3K9me) is essential for cellular homeostasis; however, its contribution to development is not well established. Here, we demonstrate that the H3K9me2 demethylase PHF2 is essential for neural progenitor proliferation in vitro and for early neurogenesis in the chicken...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pappa, Stella, Padilla, Natalia, Iacobucci, Simona, Vicioso, Marta, Álvarez de la Campa, Elena, Navarro, Claudia, Marcos, Elia, de la Cruz, Xavier, Martínez-Balbás, Marian A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765295/
https://ncbi.nlm.nih.gov/pubmed/31488723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903188116
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