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Evolution-based screening enables genome-wide prioritization and discovery of DNA repair genes

DNA repair is critical for genome stability and is maintained through conserved pathways. Traditional genome-wide mammalian screens are both expensive and laborious. However, computational approaches circumvent these limitations and are a powerful tool to identify new DNA repair factors. By analyzin...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Brunette, Gregory J., Jamalruddin, Mohd A., Baldock, Robert A., Clark, Nathan L., Bernstein, Kara A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765268/
https://ncbi.nlm.nih.gov/pubmed/31501324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906559116
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