CXCR5(+)PD-1(+) follicular helper CD8 T cells control B cell tolerance

Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4(+) T follicular helper (Tfh) cells are the main subset regulating autoreactive B cells. Here we report a CXCR5(+)PD1(+) Tfh subset of CD8(+) T cells whose development and function are negativ...

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Udgivet i:Nat Commun
Main Authors: Chen, Yuhong, Yu, Mei, Zheng, Yongwei, Fu, Guoping, Xin, Gang, Zhu, Wen, Luo, Lan, Burns, Robert, Li, Quan-Zhen, Dent, Alexander L., Zhu, Nan, Cui, Weiguo, Malherbe, Laurent, Wen, Renren, Wang, Demin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765049/
https://ncbi.nlm.nih.gov/pubmed/31562329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12446-5
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