Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility

Premature ovarian failure and infertility are adverse effects of cancer therapies. The mechanism underlying chemotherapy-mediated depletion of the ovarian reserve remains unclear. Here, we aim to identify the signaling pathways involved in the loss of the ovarian reserve to prevent the damaging effe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Bellusci, Giovanna, Mattiello, Luca, Iannizzotto, Valentina, Ciccone, Sarah, Maiani, Emiliano, Villani, Valentina, Diederich, Marc, Gonfloni, Stefania
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765024/
https://ncbi.nlm.nih.gov/pubmed/31562295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1961-y
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