Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility

Premature ovarian failure and infertility are adverse effects of cancer therapies. The mechanism underlying chemotherapy-mediated depletion of the ovarian reserve remains unclear. Here, we aim to identify the signaling pathways involved in the loss of the ovarian reserve to prevent the damaging effe...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Bellusci, Giovanna, Mattiello, Luca, Iannizzotto, Valentina, Ciccone, Sarah, Maiani, Emiliano, Villani, Valentina, Diederich, Marc, Gonfloni, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765024/
https://ncbi.nlm.nih.gov/pubmed/31562295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1961-y
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