Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D(3)

β-thalassemia is often associated with hyperglycemia, osteoporosis and increased fracture risk. However, the underlying mechanisms of the thalassemia-associated bone loss remain unclear. It might result from abnormal activities of osteoblasts and osteoclasts, and perhaps prolonged exposure to high e...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Charoenphandhu, Narattaphol, Aeimlapa, Ratchaneevan, Sooksawanwit, Supagarn, Thongbunchoo, Jirawan, Teerapornpuntakit, Jarinthorn, Svasti, Saovaros, Wongdee, Kannikar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765013/
https://ncbi.nlm.nih.gov/pubmed/31562377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50414-7
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