Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity

Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activators. High CD...

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Vydáno v:Nat Commun
Hlavní autoři: Santos, Catarina P., Lapi, Eleonora, Martínez de Villarreal, Jaime, Álvaro-Espinosa, Laura, Fernández-Barral, Asunción, Barbáchano, Antonio, Domínguez, Orlando, Laughney, Ashley M., Megías, Diego, Muñoz, Alberto, Real, Francisco X.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764959/
https://ncbi.nlm.nih.gov/pubmed/31562298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12307-1
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