Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity

Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly for >1 year. Organoid growth is dependent on EGF and Wnt activators. High CD...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Santos, Catarina P., Lapi, Eleonora, Martínez de Villarreal, Jaime, Álvaro-Espinosa, Laura, Fernández-Barral, Asunción, Barbáchano, Antonio, Domínguez, Orlando, Laughney, Ashley M., Megías, Diego, Muñoz, Alberto, Real, Francisco X.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764959/
https://ncbi.nlm.nih.gov/pubmed/31562298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12307-1
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