Potent Neutralization of Staphylococcal Enterotoxin B in vivo by antibodies that block binding to the T-cell receptor

To develop an antibody (Ab) therapeutic against Staphylococcal Enterotoxin B (SEB), a potential incapacitating bioterrorism agent and a major cause of food poisoning, we developed a “Class T” anti-SEB neutralizing Ab (GC132) targeting an epitope on SEB distinct from that of previously developed “Cla...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Chen, Gang, Karauzum, Hatice, Long, Hua, Carranza, Danielle, Holtsberg, Frederick W., Howell, Katie A., Abaandou, Laura, Zhang, Bojie, Jarvik, Nick, Ye, Wei, Liao, Grant C., Gross, Michael L., Leung, Daisy W., Amarasinghe, Gaya K., Aman, M. Javad, Sidhu, Sachdev S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764902/
https://ncbi.nlm.nih.gov/pubmed/30928493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.017
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