Potent Neutralization of Staphylococcal Enterotoxin B in vivo by antibodies that block binding to the T-cell receptor

To develop an antibody (Ab) therapeutic against Staphylococcal Enterotoxin B (SEB), a potential incapacitating bioterrorism agent and a major cause of food poisoning, we developed a “Class T” anti-SEB neutralizing Ab (GC132) targeting an epitope on SEB distinct from that of previously developed “Cla...

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Dades bibliogràfiques
Publicat a:J Mol Biol
Autors principals: Chen, Gang, Karauzum, Hatice, Long, Hua, Carranza, Danielle, Holtsberg, Frederick W., Howell, Katie A., Abaandou, Laura, Zhang, Bojie, Jarvik, Nick, Ye, Wei, Liao, Grant C., Gross, Michael L., Leung, Daisy W., Amarasinghe, Gaya K., Aman, M. Javad, Sidhu, Sachdev S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764902/
https://ncbi.nlm.nih.gov/pubmed/30928493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.03.017
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