PET Imaging of a [(18)F]-radiolabeled PARP Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in Small Cell Lung Cancer Patient-Derived Xenografts

INTRODUCTION: Inhibitors of poly-(ADP)-ribose polymerase (PARP) are promising therapeutics for small cell lung cancer (SCLC). We tested whether PARP inhibitor (PARPi) target engagement as measured by a radiolabeled PARP inhibitor ([(18)F]PARPi) has the potential to predict drug efficacy in vivo. MET...

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Udgivet i:J Thorac Oncol
Main Authors: Laird, James, Lok, Benjamin H., Carney, Brandon, Kossatz, Susanne, de Stanchina, Elisa, Reiner, Thomas, Poirier, John T., Rudin, Charles M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764879/
https://ncbi.nlm.nih.gov/pubmed/31195178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2019.05.032
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