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PET Imaging of a [(18)F]-radiolabeled PARP Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in Small Cell Lung Cancer Patient-Derived Xenografts
INTRODUCTION: Inhibitors of poly-(ADP)-ribose polymerase (PARP) are promising therapeutics for small cell lung cancer (SCLC). We tested whether PARP inhibitor (PARPi) target engagement as measured by a radiolabeled PARP inhibitor ([(18)F]PARPi) has the potential to predict drug efficacy in vivo. MET...
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| 出版年: | J Thorac Oncol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6764879/ https://ncbi.nlm.nih.gov/pubmed/31195178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2019.05.032 |
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