Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 deletion in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Deng, Qi, Li, Ping, Che, Manju, Liu, Jiajia, Biswas, Soma, Ma, Gang, He, Lin, Wei, Zhanying, Zhang, Zhenlin, Yang, Yingzi, Liu, Huijuan, Li, Baojie
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764825/
https://ncbi.nlm.nih.gov/pubmed/31482846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50208
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