Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 deletion in...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Deng, Qi, Li, Ping, Che, Manju, Liu, Jiajia, Biswas, Soma, Ma, Gang, He, Lin, Wei, Zhanying, Zhang, Zhenlin, Yang, Yingzi, Liu, Huijuan, Li, Baojie
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Cancer Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764825/
https://ncbi.nlm.nih.gov/pubmed/31482846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50208
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