Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause tumorigenesis. Here, we show that Ptch1 deletion in...

全面介紹

Na minha lista:
書目詳細資料
發表在:eLife
Main Authors: Deng, Qi, Li, Ping, Che, Manju, Liu, Jiajia, Biswas, Soma, Ma, Gang, He, Lin, Wei, Zhanying, Zhang, Zhenlin, Yang, Yingzi, Liu, Huijuan, Li, Baojie
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2019
主題:
Cancer Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764825/
https://ncbi.nlm.nih.gov/pubmed/31482846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50208
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍