P granules protect RNA interference genes from silencing by piRNAs

P granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs for self/non-self RNA discrimination by Argonautes. We report that a mutant (meg-3 meg-4) that does not assemble P granules in primordial germ cells loses competence for RNA-interference over several generation...

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Vydáno v:Dev Cell
Hlavní autoři: Ouyang, John Paul T., Folkmann, Andrew, Bernard, Lauren, Lee, Chih-Yung, Seroussi, Uri, Charlesworth, Amanda G., Claycomb, Julie M., Seydoux, Geraldine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764750/
https://ncbi.nlm.nih.gov/pubmed/31402283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.07.026
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