The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke

The aberrant activation of CDK5 has been implicated in neuronal death in stroke. The goal of this study is to determine whether knocking down CDK5 by a peptide-directed lysosomal degradation approach is therapeutically effective against stroke. We synthesized a membrane-permeable peptide that specif...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Aging Dis
Päätekijät: Zhou, Ya-Fan, Wang, Jing, Deng, Man-Fei, Chi, Bin, Wei, Na, Chen, Jian-Guo, Liu, Dan, Yin, Xiaoping, Lu, Youming, Zhu, Ling-Qiang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: JKL International LLC 2019
Aiheet:
Short Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764726/
https://ncbi.nlm.nih.gov/pubmed/31595208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2018.1225
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