Exploring mTOR inhibition as treatment for mitochondrial disease

Leigh syndrome and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke‐like episodes) are two of the most frequent pediatric mitochondrial diseases. Both cause severe morbidity and neither have effective treatment. Inhibiting the mammalian target of rapamycin (mTOR) pathway has been...

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Bibliographic Details
Published in:Ann Clin Transl Neurol
Main Authors: Sage‐Schwaede, Abigail, Engelstad, Kristin, Salazar, Rachel, Curcio, Angela, Khandji, Alexander, Garvin Jr, James H., De Vivo, Darryl C.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764630/
https://ncbi.nlm.nih.gov/pubmed/31386302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.50846
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