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Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages

BACKGROUND: Even though hypoxia-inducible factor-1α (HIF-1α) is among the transcriptional factors demonstrated to contribute to the formation of abdominal aortic aneurysms (AAAs), the precise mechanism has been unclear. Digoxin is known as an inhibitor of HIF-1α, and shows a protective effect agains...

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Publicat a:J Vasc Res
Autors principals: Igari, Kimihiro, Kelly, Matthew J., Yamanouchi, Dai
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764455/
https://ncbi.nlm.nih.gov/pubmed/31085912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000499380
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