Dexmedetomidine inhibits the NF-κB pathway and NLRP3 inflammasome to attenuate papain-induced osteoarthritis in rats

Context: Dexmedetomidine (Dex) has been reported to have an anti-inflammatory effect. However, its role on osteoarthritis (OA) has not been explored. Objective: This study investigates the effect of Dex on OA rat model induced by papain. Materials and methods: The OA Wistar rat model was induced by...

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Vydáno v:Pharm Biol
Hlavní autoři: Cheng, Fang, Yan, Feng-Feng, Liu, Yue-Peng, Cong, Yan, Sun, Ke-Fu, He, Xue-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764405/
https://ncbi.nlm.nih.gov/pubmed/31545916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13880209.2019.1651874
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