Trimetazidine ameliorates sunitinib-induced cardiotoxicity in mice via the AMPK/mTOR/autophagy pathway

Context: Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotective effects in numerous cardiovascular conditions, but its p...

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Bibliografiska uppgifter
I publikationen:Pharm Biol
Huvudupphovsmän: Yang, Yi, Li, Na, Chen, Tongshuai, Zhang, Chunmei, Liu, Lingxin, Qi, Yan, Bu, Peili
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764339/
https://ncbi.nlm.nih.gov/pubmed/31545912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13880209.2019.1657905
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