Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach

Research has shown that FMS-like tyrosine kinase 3 (FLT3) may be a vital drug target for acute myeloid leukemia (AML). However, even though the clinically relevant F691L gatekeeper mutation conferred resistance to current FLT3 drug quizartinib, PLX3397 remained unaffected. In this study, the protein...

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Bibliografiska uppgifter
I publikationen:Front Pharmacol
Huvudupphovsmän: Sun, Yunfeng, Xia, Zhongni, Zhao, Qinqin, Zheng, Bei, Zhang, Meiling, Ying, Yin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2019
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763581/
https://ncbi.nlm.nih.gov/pubmed/31619996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01050
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