First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system. We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MRgFUS...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Abrahao, Agessandro, Meng, Ying, Llinas, Maheleth, Huang, Yuexi, Hamani, Clement, Mainprize, Todd, Aubert, Isabelle, Heyn, Chinthaka, Black, Sandra E., Hynynen, Kullervo, Lipsman, Nir, Zinman, Lorne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763482/
https://ncbi.nlm.nih.gov/pubmed/31558719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12426-9
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