Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study

The blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously injected microbubbles can temporarily and repeatedly disrupt the BBB in a targeted fashion, without open surgery. Our objectiv...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Mainprize, Todd, Lipsman, Nir, Huang, Yuexi, Meng, Ying, Bethune, Allison, Ironside, Sarah, Heyn, Chinthaka, Alkins, Ryan, Trudeau, Maureen, Sahgal, Arjun, Perry, James, Hynynen, Kullervo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344541/
https://ncbi.nlm.nih.gov/pubmed/30674905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36340-0
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