The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis

BACKGROUND: Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy (ICI), one which precludes the continuation of ICI. Yet, the mechanistic underpinnings of CIP are unknown. METHODS: To better understand the mechanism of lung injury in CIP, we prosp...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Suresh, Karthik, Naidoo, Jarushka, Zhong, Qiong, Xiong, Ye, Mammen, Jennifer, de Flores, Marcia Villegas, Cappelli, Laura, Balaji, Aanika, Palmer, Tsvi, Forde, Patrick M., Anagnostou, Valsamo, Ettinger, David S., Marrone, Kristen A., Kelly, Ronan J., Hann, Christine L., Levy, Benjamin, Feliciano, Josephine L., Lin, Cheng-Ting, Feller-Kopman, David, Lerner, Andrew D., Lee, Hans, Shafiq, Majid, Yarmus, Lonny, Lipson, Evan J., Soloski, Mark, Brahmer, Julie R., Danoff, Sonye K., D’Alessio, Franco
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2019
Aiheet:
Clinical Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763233/
https://ncbi.nlm.nih.gov/pubmed/31310589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128654
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