The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis

BACKGROUND: Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy (ICI), one which precludes the continuation of ICI. Yet, the mechanistic underpinnings of CIP are unknown. METHODS: To better understand the mechanism of lung injury in CIP, we prosp...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Clin Invest
المؤلفون الرئيسيون: Suresh, Karthik, Naidoo, Jarushka, Zhong, Qiong, Xiong, Ye, Mammen, Jennifer, de Flores, Marcia Villegas, Cappelli, Laura, Balaji, Aanika, Palmer, Tsvi, Forde, Patrick M., Anagnostou, Valsamo, Ettinger, David S., Marrone, Kristen A., Kelly, Ronan J., Hann, Christine L., Levy, Benjamin, Feliciano, Josephine L., Lin, Cheng-Ting, Feller-Kopman, David, Lerner, Andrew D., Lee, Hans, Shafiq, Majid, Yarmus, Lonny, Lipson, Evan J., Soloski, Mark, Brahmer, Julie R., Danoff, Sonye K., D’Alessio, Franco
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2019
الموضوعات:
Clinical Medicine
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763233/
https://ncbi.nlm.nih.gov/pubmed/31310589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128654
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