The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis

BACKGROUND: Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy (ICI), one which precludes the continuation of ICI. Yet, the mechanistic underpinnings of CIP are unknown. METHODS: To better understand the mechanism of lung injury in CIP, we prosp...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Suresh, Karthik, Naidoo, Jarushka, Zhong, Qiong, Xiong, Ye, Mammen, Jennifer, de Flores, Marcia Villegas, Cappelli, Laura, Balaji, Aanika, Palmer, Tsvi, Forde, Patrick M., Anagnostou, Valsamo, Ettinger, David S., Marrone, Kristen A., Kelly, Ronan J., Hann, Christine L., Levy, Benjamin, Feliciano, Josephine L., Lin, Cheng-Ting, Feller-Kopman, David, Lerner, Andrew D., Lee, Hans, Shafiq, Majid, Yarmus, Lonny, Lipson, Evan J., Soloski, Mark, Brahmer, Julie R., Danoff, Sonye K., D’Alessio, Franco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763233/
https://ncbi.nlm.nih.gov/pubmed/31310589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128654
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